000			03401cam a2200409 i 4500
001			on1040032074
003			OCoLC
005			20250612155501.0
006			m o d
007			cr cnu|||unuuu
008			180613s2018 ne ob 001 0 eng d
040			_aN$T _beng _erda _epn _cN$T _dN$T _dYDX _dEBLCP _dOPELS _dMERER _dOCLCF _dOCLCQ _dOTZ _dNLE _dSNK _dU3W _dLVT _dD6H _dOCLCQ _dS2H _dOCLCO _dOCLCQ _dOCLCO _dK6U _dOCLCQ _dSFB _dOCLCQ _dOCLCO _dSXB _dOCLCQ _dUKKRT
019			_a1040622177 _a1041521666
020			_a9780081021057 _q(electronic bk.)
020			_a0081021054 _q(electronic bk.)
020			_z9780081020838 _q(print)
020			_z008102083X
035			_a(OCoLC)1040032074 _z(OCoLC)1040622177 _z(OCoLC)1041521666
050		4	_aRS403
072		7	_aMED _x071000 _2bisacsh
082	0	4	_a615.1/9 _223
245	0	0	_aKey heterocycle cores for designing multitargeting molecules / _cedited by Om Silakari.
264		1	_aAmsterdam, Netherlands : _bElsevier, _c2018.
300			_a1 online resource
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
504			_aIncludes bibliographical references and index.
588	0		_aOnline resource; title from PDF title page (Ebsco, viewed June 14, 2018).
520			_aKey Heterocycle Cores for Designing Multitargeting Molecules provides a helpful overview of current developments in the field. Following a detailed introduction to the manipulation of heterocycle cores for the development of dual or multitargeting molecules, the book goes on to describe specific examples of such developments, focusing on compounds such as Benzimidazole, Acridine, Flavones, Thiazolidinedione and Oxazoline. Drawing on the latest developments in the field, this volume provides a valuable guide to current approaches in the design and development of molecules capable of acting on multiple targets. Adapting the heterocyclic core of a single-target molecule can facilitate its development into an agent capable of acting on multiple targets. Such multi-targeting drugs have the potential to become essential components in the design of novel, holistic treatment plans for complex diseases, making the design of such active agents an increasingly important area of research.
505	0		_a1. Multitargeting heterocycles -- An improved and rational chemical probes for multifactorial diseases 2. Benzimidazole: Journey from a single targeting to a multitargeting nucleus 3. Acridines:A relatively lesser explored heterocycle for multifactorial diseases 4. Flavone: An important scaffold for medicinal chemistry 5. Thiazolidine-2, 4-dione: a potential weapon for targeting multiple pathological conditions 6. Oxindole:A nucleus enriched with multi-targeting potential against complex disorders 7. Thiazine: A Versatile Heterocyclic Scaffold for Multifactorial Diseases 8. Indole: As multi-target directed ligands in medicinal chemistry 9. Triazoles: Multidimensional 5-membered nucleus for designing multitargeting agents 10. Benzoxazolinone:A scaffold with diverse pharmacological significance
650		0	_aPharmaceutical chemistry. _925855
650		0	_aHeterocyclic compounds. _96438
700	1		_aSilakari, Om, _eeditor. _934171
776	0	8	_iPrint version: _z008102083X _z9780081020838 _w(OCoLC)1004360838
856	4	0	_3ScienceDirect _uhttps://www.sciencedirect.com/science/book/9780081020838
999			_c216467 _d216467