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| 001 | on1039079230 | ||
| 003 | OCoLC | ||
| 005 | 20250612155501.0 | ||
| 006 | m o d | ||
| 007 | cr cnu|||unuuu | ||
| 008 | 180607s2018 ne a ob 001 0 eng d | ||
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| 020 | _z9780128112922 | ||
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_aPalladium-catalyzed modification of nucleosides, nucleotides and oligonucleotides / _cedited by Anant R. Kapdi, Debabrata Maiti, Yogesh S. Sanghvi. |
| 264 | 1 |
_aAmsterdam, Netherlands : _bElsevier, _c[2018] |
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| 300 |
_a1 online resource : _billustrations |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 490 | 1 | _aLatest trends in palladium chemistry | |
| 504 | _aIncludes bibliographical references and index. | ||
| 588 | 0 | _aOnline resource; title from PDF title page (EBSCO, viewed June 11, 2018). | |
| 505 | 0 | _aFront Cover; Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides; Copyright; Contents; Contributors; Chapter 1: The Future of Drug Discovery: The Importance of Modified Nucleosides, Nucleotides, and Oligonucleotides; 1. Introduction; 2. Biologically Active Modified Nucleosides; 3. Synthetic Fluorescent Nucleoside Analogs; 4. Oligonucleotide Applications; 5. An Overview of Other Cross-Coupling Reactions in This Book; 6. Stille Cross-Coupling; 7. Suzuki-Miyaura Cross-Coupling; 8. Sonogashira reactions; 9. Heck Cross-Coupling. | |
| 505 | 8 | _a10. Buchwald-Hartwig reactions11. C-H Activation Reactions; 12. Cross-Coupling of Nucleotides and Oligonucleotides; 13. Summary and Future Directions; References; Chapter 2: Stille Cross-Coupling Reaction: Early Years to the Current State of the Art; 1 Introduction; 2. Stille Coupling Reactions; 2.1 Early Developments; 3 Conclusion; References; Chapter 3: Suzuki-Miyaura Cross-Coupling as a Synthetic Tool for Nucleoside and Nucleotide Modification; 1. Introduction; 2. Suzuki-Miyaura Reaction: Mechanism and Conditions; 2.1 Overview of the Reaction. | |
| 505 | 8 | _a2.2 Suzuki-Miyaura Reaction in Various Water-Based Catalytic Systems2.2.1 In Tetrahydrofuran/Methanol/Water; 2.2.2 In Dimethylether/Water; 2.2.3 In DMF/H2O; 2.2.4 In ACN/H2O; 2.2.5 In MeOH/H2O; 2.2.6 In H2O; 3. Palladium-Catalyzed Suzuki-Miyaura Routes to Modified Nucleosides; 3.1 Purine Nucleoside Analogues; 3.1.1 Modified Nucleosides at Purine Moiety; 3.1.2 Modified Flexible Nucleosides; 3.1.3 Carbocyclic Nucleosides Analogues; 3.2 Pyrimidine-Modified Analogues; 3.2.1 Arylation at C5- and C6- of Uridine/Cytidine Moiety. | |
| 505 | 8 | _a3.2.2 Arylation of C5-Halo Uridine/Cytidine and C7-Halo Purine Nucleotides3.3 Miscellaneous; 4. Concluding Remarks; Acknowledgments; References; Chapter 4: Sonogashira Cross-Coupling: Alkyne-Modified Nucleosides and Their Applications; 1. Introduction; 2. General Reaction and the Mechanism of Classical Sonogashira Reaction; 3. Modifications of Sonogashira Coupling; 3.1 Modifications of Ligated Pd-Catalysts; 3.2 Generation of Ligand-Free Palladium Catalysts; 3.3 Palladium Nanoparticles as Catalysts. | |
| 505 | 8 | _a3.4 Modified Form of Cu(I)-Co-Catalyst: Click Reagent Version of Sonogashira Coupling: Contribution From Our Group3.5 Cu-Free Sonogashira Coupling; 3.6 Ligand, Copper, and Amine-Free Palladium Catalyzed Sonogashira Coupling; 4. Applications of the Sonogashira Reaction; 5. Sonogashira Reaction in the Synthesis of Nucleoside; 6. Application of Sonogashira Coupling to Pyrimidine Nucleosides; 6.1 Synthesis of C-4-Substituted Pyrimidines; 6.2 Synthesis of C-5-Substituted Pyrimidines; 7. Sonogashira Coupling for the Synthesis of Substituted Purine Nucleosides. | |
| 520 | 8 |
_aAnnotation _bThis volume describes the procedures and protocols related to the modification of nucleosides, nucleotides and oligonucleotides via Pd-mediated cross-coupling processes. The book highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist this development. |
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| 650 | 0 |
_aPalladium catalysts. _934164 |
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| 650 | 0 |
_aNucleosides. _926295 |
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| 650 | 0 |
_aNucleotides. _92960 |
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| 650 | 0 |
_aOligonucleotides. _934165 |
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| 700 | 1 |
_aKapdi, Anant R., _eeditor. _934166 |
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| 700 | 1 |
_aMaiti, Debabrata, _eeditor. _934167 |
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| 700 | 1 |
_aSanghvi, Yogesh S., _d1956- _eeditor. _1https://id.oclc.org/worldcat/entity/E39PCjKBKgBxGVByFc7DbB9qwC _934168 |
|
| 758 |
_ihas work: _aPalladium-catalyzed modification of nucleosides, nucleotides and oligonucleotides (Text) _1https://id.oclc.org/worldcat/entity/E39PCG6mHYG3Gr447H4HqhrJcP _4https://id.oclc.org/worldcat/ontology/hasWork |
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| 776 | 0 | 8 |
_iPrint version: _tPalladium-catalyzed modification of nucleosides, nucleotides and oligonucleotides. _dAmsterdam, Netherlands : Elsevier, [2018] _z9780128112922 _z0128112921 _w(OCoLC)1002834729 |
| 830 | 0 |
_aLatest trends in palladium chemistry. _934169 |
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| 856 | 4 | 0 |
_3ScienceDirect _uhttps://www.sciencedirect.com/science/book/9780128112922 |
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_c216465 _d216465 |
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