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019 _a923546172
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020 _a9780124116207
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020 _a0124116205
_q(electronic bk.)
020 _a0124115969
020 _a9780124115965
020 _z9780124115965
020 _z0124115969
024 3 _a9780124116207
024 3 _a9780124115965
035 _a(OCoLC)919087033
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_z(OCoLC)929142666
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_z(OCoLC)1066627783
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050 4 _aQP86
060 4 _aWT 104
_bH236 2016
072 7 _aSCI
_x056000
_2bisacsh
082 0 4 _a571.8/78
_223
245 0 0 _aHandbook of the biology of aging /
_cedited by Matt R. Kaeberlein and George M. Martin.
250 _aEighth edition.
264 1 _aAmsterdam :
_bElsevier Ltd.,
_c2016.
264 4 _c�2016
300 _a1 online resource (xvi, 559 pages) :
_billustrations
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aHandbooks of aging ;
_vvolume 3
504 _aIncludes bibliographical references and indexes.
588 0 _aOnline resource; title from PDF title page (EBSCO, viewed August 26, 2015).
505 0 _aI. Basic Mechanisms of Aging: Models and Systems -- 1 Longevity as a Complex Genetic Trait -- 2 The mTOR Pathway and Aging -- 3 Sirtuins, Healthspan, and Longevity in Mammals -- 4 The Hypoxic Response and Aging -- 5 The Role of Neurosensory Systems in the Modulation of Aging -- 6 The Naked Mole-Rat: A Resilient Rodent Model of Aging, Longevity, and Healthspan -- 7 Contributions of Telomere Biology to Human Age-Related Disease -- 8 Systems Approaches to Understanding Aging -- 9 Integrative Genomics of Aging -- 10 NIA Interventions Testing Program: A Collaborative Approach for Investigating Interventions to Promote Healthy Aging -- 11 Comparative Biology of Aging: Insights from Long-Lived Rodent Species -- II. The Pathobiology of Human Aging -- 12 Genetics of Human Aging -- 13 The Aging Arterial Wall -- 14 Age-Related Alterations in Neural Plasticity -- 15 The Aging Immune System: Dysregulation, Compensatory Mechanisms, and Prospects for Intervention -- 16 Vascular Disease in Hutchinson Gilford Progeria Syndrome and Aging: Common Phenotypes and Potential Mechanisms -- 17 Cardiac Aging -- 18 Current Status of Research on Trends in Morbidity, Healthy Life Expectancy, and the Compression of Morbidity -- 19 On the Compression of Morbidity: From 1980 to 2015 and Beyond
520 _aHandbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussion.
504 _aIncludes bibliographical references and index.
650 0 _aAging
_xPhysiological aspects
_vHandbooks, manuals, etc.
_933815
655 0 _aElectronic book.
700 1 _aKaeberlein, Matt,
_d1971-
_eeditor.
_1https://id.oclc.org/worldcat/entity/E39PBJk4y9vv67FwwMYpMj8Bfq
_933816
700 1 _aMartin, George M.,
_d1927-
_eeditior.
_1https://id.oclc.org/worldcat/entity/E39PBJbWvgf9hFwvrPym4Cp773
_933817
776 0 8 _iPrint version:
_aKaeberlein, Matt.
_tHandbook of the Biology of Aging.
_d: Elsevier Science, �2015
_z9780124115965
830 0 _aHandbooks of aging ;
_vv. 3.
_933442
856 4 0 _3ScienceDirect
_uhttps://www.sciencedirect.com/science/book/9780124115965
999 _c216343
_d216343