Mass spectrometry in medicinal chemistry/ edited by Klaus T. Wanner and Georg Ho fner.

Mass spectrometry in bioanalysis : methods, principles and instrumentation / Gérard Hopfgartner -- Drug screening using gel permeation chromatography spin columns coupled with ESI-MS / Marshall M. Siegel --ALIS : an affinity selection-mass spectrometry system for the discovery and characterization of protein-ligand interactions / Allen Annis, Cheng-Chi Chuang, Naim Nazef -- Library screening using ultrafiltration and mass spectrometry / Timothy E. Cloutier, Kenneth M. Comess -- Continuous flow systems for ligand binding and enzyme inhibition assays based on mass spectrometry / Hubertus Irth -- Frontal affinity chromatography : mass spectrometry for ligand discovery and characterization / Nora Chan, Darren Lewis, Michele Kelly, Ella S.M. Ng, David C. Schriemer -- MS binding assays : an alternative to radioligand binding / Georg Hö̈fner, Christine Zepperitz, Klaus T. Wanner -- Laser desorption assays : MALDI-MS, DIOS-MS, and SAMDI-MS / Martin Vogel, Andy Scheffer, André Liesener, Uwe Karst -- Tethering : fragment-based drug discovery by mass spectrometry / Mark T. Cancilla, Daniel A. Erlanson -- Interrogation of noncovalent complexes by ESI-MS : a powerful platform for high throughput drug discovery / Steven A. Hofstadler, Kristin A. Sannes-Lowery -- Quantification of protein-ligand interactions in solution by hydrogen/deuterium exchange (PLIMSTEX) / Mei M. Zhu, David Hambly, Michael L. Gross -- Protein-targeting drug discovery guided by hydrogen/deuterium exchange mass spectrometry (DXMS) / Yoshitomo Hamuro, Stephen J. Coales, Virgil L. Woods, Jr. -- Mass spectrometry in early pharmacokinetic investigations / Walter A. Korfmacher.