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Precision medicine and the reinvention of human disease / Jules J. Berman.

By: Berman, Jules J [author.]Material type: Text

TextPublisher: London, UK : Academic Press, an imprint of Elsevier, [2018]Description: 1 online resourceContent type: text Media type: computer Carrier type: online resourceISBN: 9780128143940; 0128143940Subject(s): Genomics | Precision medicine | Pharmacogenetics | Human chromosome abnormalities -- Diagnosis | Human beingsAdditional physical formats: Print version:: No titleDDC classification: 615.8/95 LOC classification: RM301.3.G45 | B47 2018ebNLM classification: 2018 D-100 | WB 102Online resources: ScienceDirect

Contents:

Introduction: seriously, what is precision medicine? -- Redefining disease causality -- Genetics: clues, not answers to the mysteries of precision medicine -- Disease convergence -- The precision of the rare diseases -- Precision organisms -- Reinventing diagnosis -- Precision data -- The alternate futures of precision medicine.

Summary: Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution.

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Includes bibliographical references and index.

Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution.

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