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Handbook of the biology of aging / edited by Matt R. Kaeberlein and George M. Martin.

Contributor(s): Kaeberlein, Matt, 1971- [editor.] | Martin, George M, 1927- [editior.]Material type: Text

TextSeries: Handbooks of aging ; v. 3.Publisher: Amsterdam : Elsevier Ltd., 2016Copyright date: �2016Edition: Eighth editionDescription: 1 online resource (xvi, 559 pages) : illustrationsContent type: text Media type: computer Carrier type: online resourceISBN: 9780124116207; 0124116205; 0124115969; 9780124115965Subject(s): Aging -- Physiological aspects -- Handbooks, manuals, etcGenre/Form: Electronic book.Additional physical formats: Print version:: Handbook of the Biology of Aging.DDC classification: 571.8/78 LOC classification: QP86NLM classification: WT 104Online resources: ScienceDirect

Contents:

I. Basic Mechanisms of Aging: Models and Systems -- 1 Longevity as a Complex Genetic Trait -- 2 The mTOR Pathway and Aging -- 3 Sirtuins, Healthspan, and Longevity in Mammals -- 4 The Hypoxic Response and Aging -- 5 The Role of Neurosensory Systems in the Modulation of Aging -- 6 The Naked Mole-Rat: A Resilient Rodent Model of Aging, Longevity, and Healthspan -- 7 Contributions of Telomere Biology to Human Age-Related Disease -- 8 Systems Approaches to Understanding Aging -- 9 Integrative Genomics of Aging -- 10 NIA Interventions Testing Program: A Collaborative Approach for Investigating Interventions to Promote Healthy Aging -- 11 Comparative Biology of Aging: Insights from Long-Lived Rodent Species -- II. The Pathobiology of Human Aging -- 12 Genetics of Human Aging -- 13 The Aging Arterial Wall -- 14 Age-Related Alterations in Neural Plasticity -- 15 The Aging Immune System: Dysregulation, Compensatory Mechanisms, and Prospects for Intervention -- 16 Vascular Disease in Hutchinson Gilford Progeria Syndrome and Aging: Common Phenotypes and Potential Mechanisms -- 17 Cardiac Aging -- 18 Current Status of Research on Trends in Morbidity, Healthy Life Expectancy, and the Compression of Morbidity -- 19 On the Compression of Morbidity: From 1980 to 2015 and Beyond

Summary: Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussion.

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Includes bibliographical references and indexes.

Online resource; title from PDF title page (EBSCO, viewed August 26, 2015).

Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussion.

Includes bibliographical references and index.

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