TY - BOOK AU - Walsh, Christopher. TI - Antibiotics: aqctions, origins, resistance SN - 1555818935 U1 - 615.329 PY - 2003/// CY - Washington PB - ASM Press KW - Antibiotics KW - Drug resistance in microorganisms N1 - 1 Antibiotics : initial concepts 2 Introduction to major antibiotic classes and modes of action 3 Antibiotics that act on cell wall biosynthesis 4 Antibiotics that block bacterial protein biosynthesis 5 Antibiotics that block DNA replication and repair : the Quinolones 6 Other targets of antibacterial drugs 7 Natural and producer immunity versus acquired resistance 8 Enzymatic destruction or modification of the antibiotic by resistant bacteria 9 Antibiotic resistance by efflux pumps 10 Antibiotic resistance by replacement or modification of the antibiotic target 11 Regulation of antibiotic biosynthesis in producer organisms 12 Polyketide antibiotic biosynthesis : assembly line enzymology 13 Enzymatic assembly lines for nonribosomal peptide antibiotics 14 Biosynthesis of other classes of antibiotics 15 New looks at targets 16 New molecules 17 Contexts and challenges for the use of new antibiotics ER -