1 Introduction 2 The "Early Days" of Nucleic Acids 3 Genetic Engineering and Reverse Genetics 4 Cell Structures and Functions 5 Cellular Dynamics 6 Anatomy of the Transcription Machinery and Auxiliary Complexes: Chromatin Remodeling 7 Molecular Signalling Cascades and Gene Regulation 8 Yeast Organellar Biogenesis and Function 9 Genome, Proteome, Transcriptome, Metabolome, and Regulatory Networks 10 Disease Genes in Yeast 11 Yeast Biotechnology 12 Epilogue: The Future of Yeast Research