TY - BOOK AU - Calam, C.T. TI - Process development in antibiotic fermentations SN - 0521065526 U1 - 615.392 PY - 2008/// CY - Cambridge PB - Cambridge University KW - Antibiotics -- Synthesis. KW - Pharmaceutical microbiology. KW - Fermentation N1 - Preface Part I. Background 1. Introduction 2. The microorganisms and methods of culture 3. Microbial physiology 4. Microbial biochemistry 5. Subsidiary factors important in production fermentations 6. Submerged culture conditions: the interaction between environment and genotype Part II. Process Development in the Laboratory 7. Laboratory fermentation process development 8. Assessment and understanding of experimental results 9. Strain improvement 10. Methods for laboratory process development Part III. Industrial Fermentation Plants and Pilot Plants 11. Fermentation plants and pilot plants 12. Process development in the fermentation plant 13. Two plant problems: infection and variations in the level of production Postscript Bibliography References Index ER -