Mass spectrometry in drug discovery/
Rossi, David T.
- 1st ed.
- New York: Marcel and Dekker, 2002.
- 420 p.
I Introduction 1 Demand for drug discovery today 2 The impact of atmospheric pressure ionization
II Instrumentation 3 A mass spectrometry primer
III Experimental strategies 4 Ion chemistry and fragmentation 5 The LC/MS experiment 6 Sample preparation and handling for LC/MS in drug discovery
IV Applications 7 Mass spectrometry in combinatorial chemistry 8 Drug hydrophobicity and transport 9 The mass spectrometer in drug metabolism 10 Mass spectrometry-assisted applications of stable-labeled compounds in pharmacokinetic and drug metabolism studies 11 Cassette dosing in drug discovery 12 Applications of microdialysis/mass spectrometry to drug discovery 13 Future directions for mass spectrometry in drug discovery