Computational Methods for Processing and Analysis of Biological Pathways [electronic resource] / by Anastasios Bezerianos, Andrei Dragomir, Panos Balomenos.
Material type: TextSeries: SpringerBriefs in Computer SciencePublisher: Cham : Springer International Publishing : Imprint: Springer, 2017Edition: 1st ed. 2017Description: VIII, 87 p. 11 illus. in color. online resourceContent type: text Media type: computer Carrier type: online resourceISBN: 9783319538686Subject(s): Bioinformatics | Systems biology | Computational Biology/Bioinformatics | Systems BiologyDDC classification: 570.285 LOC classification: QH324.2-324.25Online resources: Click here to access onlineItem type | Current library | Call number | Status | Date due | Barcode | Item holds |
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e-Books | Central Library, Sikkim University | 570.285 (Browse shelf(Opens below)) | Not for loan | E-2991 |
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Introduction -- Networks and Pathways in Systems Pharmacology -- Time Varying Methods for Pathway and Sub-Pathway Analysis -- Identification of Differentially Expressed Pathways and Sub-Pathways.
This work offers a guided walkthrough of one of the most promising research areas in modern life sciences, enabling a deeper understanding of involved concepts and methodologies via an interdisciplinary view, focusing on both well-established approaches and cutting-edge research. Highlighting what pathway analysis can offer to both the experimentalist and the modeler, the text opens with an introduction to a general methodology that outlines common workflows shared by several methods. This is followed by a review of pathway and sub-pathway based approaches for systems pharmacology. The work then presents an overview of pathway analysis methods developed to model the temporal aspects of drug- or disease-induced perturbations and extract relevant dynamic themes. The text concludes by discussing several state-of-the-art methods in pathway analysis, which address the important problem of identifying differentially expressed pathways and sub-pathways.
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