Mass spectrometry in drug discovery/
Mass spectrometry in drug discovery/
Rossi, David T.
- 1st ed.
- New York: Marcel and Dekker, 2002.
- 420 p.
I Introduction
1 Demand for drug discovery today
2 The impact of atmospheric pressure ionization
II Instrumentation
3 A mass spectrometry primer
III Experimental strategies
4 Ion chemistry and fragmentation
5 The LC/MS experiment
6 Sample preparation and handling for LC/MS in drug discovery
IV Applications
7 Mass spectrometry in combinatorial chemistry
8 Drug hydrophobicity and transport
9 The mass spectrometer in drug metabolism
10 Mass spectrometry-assisted applications of stable-labeled compounds in pharmacokinetic and drug metabolism studies
11 Cassette dosing in drug discovery
12 Applications of microdialysis/mass spectrometry to drug discovery
13 Future directions for mass spectrometry in drug discovery
9780824706074
543.0873 / ROS/M
I Introduction
1 Demand for drug discovery today
2 The impact of atmospheric pressure ionization
II Instrumentation
3 A mass spectrometry primer
III Experimental strategies
4 Ion chemistry and fragmentation
5 The LC/MS experiment
6 Sample preparation and handling for LC/MS in drug discovery
IV Applications
7 Mass spectrometry in combinatorial chemistry
8 Drug hydrophobicity and transport
9 The mass spectrometer in drug metabolism
10 Mass spectrometry-assisted applications of stable-labeled compounds in pharmacokinetic and drug metabolism studies
11 Cassette dosing in drug discovery
12 Applications of microdialysis/mass spectrometry to drug discovery
13 Future directions for mass spectrometry in drug discovery
9780824706074
543.0873 / ROS/M